The Effect of Neurotoxicity of Mangane Chloride on Corpus Striatum of Mouse Embryos

Purpose: Manganese, are of the elements plenty & which is found in nature, is widely used in Agricalture and in dustry.For years, toxicity of magnasium and its derivatives has been proven yet the findings are not valid enough to overgeneralize the result to human.In the present study the effect of neurotoxicity of manganese chloride on the mouse cortex was investigated. Materials and Methods: Pregnant mice were devided into too groups: one control, and the other experimental. In the experimental group 45 mg/kg MnCl2 were injected intrapertioneally on the seventh, eigth and ninght of gestation period and the distilled water was injected into control group. Embryos were then removed on the day 15. Embryos were weighted and fixed in Buin solution. After tissue passage procedures, samples of 5 µ were prepared sections and stained with Hematoxiline, eosine. Then the samples were evaluated. Results: Macroscopic measurements showed that embryos weights on the days 7, 8 and 9 significantly decreased in experimental group comparing with controls. Thickness of corpus striatum showed significant reduction on the day 7 & 8 in experimental group comparing with control. In experimental group gliosis were also observed. Conclusion: The results indicated that manganese chloide had toxic effects. Therefore, pregnants should not be exposed to high levels MnCl2.